A study conducted by a team led by researchers at the Farber Institute for Neurosciences at Thomas Jefferson University in Philadelphia and Edith Cowan University in Joondalup, Western Australia has shown that being extremely overweight or obese increases the likelihood of developing Alzheimer's.
Researchers found a strong correlation between body mass index and high levels of beta-amyloid, the sticky protein substance that builds up in the Alzheimer's brain and is thought to play a major role in destroying nerve cells and in cognitive and behavioural problems associated with the disease, claims the university release.
"We looked at the levels of beta-amyloid and found a relationship between obesity and circulating amyloid," said Sam E. Gandy, director of the Farber Institute for Neurosciences.
Dr. Gandy, who is also professor of neurology, and biochemistry and molecular biology at Jefferson Medical College of Thomas Jefferson University said, "Heightened levels of amyloid in the blood vessels and the brain indicate the start of the Alzheimer's process."
According to, Dr. Gandy, evidence has emerged over the last five years that many of the conditions that raise the risk for heart disease such as obesity, uncontrolled diabetes, hypertension and hypercholesterolemia also increase the risk for Alzheimer's. Yet exactly how such factors made an individual more likely to develop Alzheimer's remained a mystery.
Dr. Gandy, Ralph Martins of Edith Cowan University and their colleagues measured body mass index and beta-amyloid levels in the blood. They also looked at several other factors associated with heart disease and diabetes, such as the inflammatory marker C-reactive protein, insulin, and high density lipoprotein in 18 healthy adults who were either extremely overweight or obese. They found a statistically significant correlation between body mass index and beta-amyloid.
"Ours is one of the first attempts to try to find out on both the pathological and the molecular levels how obesity was increasing the risk of Alzheimer's," said Dr. Gandy.
One implication of these findings could be that by losing excess weight and maintaining normal body weight, an individual might reduce the risk of developing Alzheimer's. However, this has not been proven, he noted.
The next step is to follow such patients over the long term to see how many do indeed develop Alzheimer's.
"We need to first develop a medicine that is effective in humans in lowering amyloid accumulation or generation," said Dr Grandy, adding "We have those now in mice and we are testing them in humans. If we can develop such a medicine, then the question will be, if we can lower amyloid, will that in fact prevent Alzheimer's?"