The European Commission has approved Exelon Patch (rivastigmine transdermal patch), an innovative way to deliver this effective medicine to patients suffering from mild to moderately severe Alzheimer's disease.
Exelon Patch is the first and only transdermal treatment for Alzheimer's disease, a degenerative brain disorder affecting 18 million people worldwide and the third leading cause of death behind cardiovascular disease and cancer. The skin patch is applied once daily to the back, chest or upper arm of patients, the company press release said.
"Exelon Patch represents a therapeutic innovation that is designed specifically to meet the needs of patients, caregivers and physicians involved with this devastating disease. The Patch has been shown to increase compliance, reduce side effects, and allow medication to be delivered through the skin into the bloodstream smoothly and continuously over 24 hours, helping to achieve optimal dosing. All these benefits offer the potential for improved outcomes in patients," said, James Shannon, MD, global head of development, Novartis Pharma AG.
The European Union approval, coming soon after the US approval in July 2007, was based on results from the international ideal (investigation of transdermal Exelon in alzheimer's disease) study, which involved nearly 1,200 patients with mild to moderate Alzheimer's disease.
The Patch showed similar efficacy to the highest doses of Exelon capsules, as well as significant improvement in memory and the ability to perform everyday activities compared to placebo. In addition, the ideal study demonstrated three times fewer reports of gastrointestinal side effects (nausea and vomiting) with the patch than the oral form of the medication.
"The patch is an important new addition to existing oral treatment options since it provides visual reassurance that patients have 'taken' their medicine. Just having to apply a patch can help reduce the burden of daily life for people with Alzheimer's disease and their families," said, Bruno Dubois, Professor of Neurology at the Hôpital Pitié Salpétrière, Centre de Neuropsychologie, Paris, France.
Designed with compliance in mind, the patch was preferred by more than 70 per cent of caregivers as a method of drug delivery because it helped them follow treatment schedules and was easier to use than an oral medicine.
"People with Alzheimer's disease and their caregivers welcome every new therapy for the disease. I am pleased that the patch offers a new approach to treatment," said Mark Wortmann, Executive Director of Alzheimer's Disease International - an umbrella organization of Alzheimer Associations around the world, which offers support and advice to people with the disease and their carers.
Exelon (rivastigmine) in capsule form has been approved since 1997 to treat patients with mild to moderate Alzheimer's disease in more than 70 countries.
Since 2006, Exelon in capsule form or oral solution has been the only member of the cholinesterase inhibitor class of medicines that is approved in both Europe and the US for treating mild to moderate alzheimer's disease as well as Parkinson's disease dementia. On July 6, 2007, the US Food and Drug Administration (FDA) approved Exelon patch (rivastigmine transdermal system) for the treatment of mild to moderate Alzheimer's disease and Parkinson's disease dementia. Alzheimer's disease affects one in 10 people over age 65, making it the most common form of dementia.