Compugen Ltd have signed a collaboration agreement with Bayer Schering Pharma AG, Germany covering the further evaluation of a Compugen discovered tumour target and its splice variants. Following an initial six month joint research stage, the agreement provides Bayer with an option for an exclusive worldwide royalty bearing license for development of monoclonal antibodies and other therapeutic agents addressing these novel target molecules. The existence of the target and its splice variants was initially predicted in silico by Compugen through the use of its Monoclonal Antibody (mAb) Targets Discovery Platform; the predicted molecules were then validated experimentally.
The newly discovered tumour target and its splice variants are previously unknown splice variants of a known cancer target for which therapeutic agents are currently in pre-clinical development by other organizations. Like the known cancer target, this protein molecule and its variants are all trans-membrane proteins. However, each of the Compugen molecules has a unique sequence at the extracellular domain of the protein that enables the development of monoclonal antibodies specific to each of the respective splice variants. Therefore each splice variant could represent a novel target for monoclonal antibody therapy.
A common feature of Compugen's discovery platforms, such as the mAb Targets Discovery Platform used in this discovery, is the ability to predict and select multiple potential product candidates for each indication of interest. The availability of multiple candidates, in this case a number of different splice variants, should increase the probability of success for the overall program.
Dr Anat Cohen-Dayag, co-CEO of Compugen said, "Usage of our mAb Targets Discovery Platform is now providing us with a growing inventory of novel target candidates, such as the specific targets covered by this agreement, displaying differential expression in a range of tumour vs. healthy samples. Discovery of target candidates is a key step in the development of monoclonal antibody biotherapeutics for both solid tumours such as ovarian cancer, lung cancer, and colon cancer, as well as haematological malignancies such as multiple myeloma, acute and chronic leukaemia and Non Hodgkin lymphoma; and, we are now seeing a growing interest in both our existing target candidates and further applications of the platform. We are therefore very enthusiastic about the clinical and commercial potential for this unique discovery platform and are especially pleased to enter into this collaboration with Bayer Schering Pharma, a world leading pharmaceutical company."
About Compugen's Monoclonal Antibody (mAb) Targets Discovery PlatformDuring the past two decades, monoclonal antibodies have emerged as an important and rapidly growing new drug class, and identifying the appropriate targets is recognized as the key discovery requirement. In addition, this class of drugs has demonstrated a higher probability of success in clinical development in comparison with other drug classes. Compugen's mAb Targets Discovery Platform relies on Compugen's LEADS and MED capabilities, two proprietary infrastructure platforms that power, together or separately, a number of the Company's ten existing product candidate discovery platforms. LEADS provides a comprehensive view of the human transcriptome, proteome, and peptidome, allowing the discovery of numerous novel genes, proteins, and peptides. It includes extensive gene and protein information and annotation, such as splice variants, antisense genes, SNPs, novel genes, chimeric genes and RNA editing. The MED Platform provides an integrated database composed of the results from more than 40,000 public and proprietary microarray experiments, normalized and organized into approximately 1,400 therapeutically relevant conditions (i.e. normal tissues, malignant tissues, tissues from drug treated patients, etc.). Utilizing a sophisticated query interface, the MED platform allows the examination of the expression of genes and pathways across all 1,400 tissues and conditions simultaneously.
In addition to incorporating MED and LEADS, the mAb Targets Discovery Platform utilizes multiple data sources and algorithms to predict a large number of novel membrane proteins that can serve as targets for antibody therapeutics, such as for various cancer and autoimmune diseases. The selection of appropriate candidates from this large body of predicted membrane proteins is accomplished using sub-modules of algorithms and other computational tools developed specifically for each disease state or protein family.
Compugen is a leading drug and diagnostic product candidate discovery company.