Lab major Waters has developed a range of products that will help research centres to speed up studies and enable them to generate findings at a faster pace.
The $1.5 billion company having around 5,200 employees, has pioneered a portfolio of separations science, laboratory information management, mass spectrometry and thermal analysis. Waters’ technology breakthroughs and laboratory solutions provide an enduring platform for customer success.
The company’s new range of four products are Protein-Pak which is a new Ion-Exchange Columns for Protein Characterization, UPLC SEC solution for protein characterization, maintenance, repair and compliance services and Patrol UPLC System.
The Protein-Pak Hi Res, Ion-Exchange (IEX) columns is designed for use with Waters Acquity UltraPerformance LC (UPLC) System for the analysis of biomolecules including monoclonal antibodies, recombinant proteins, DNA/RNA, and vaccine components. These columns give biopharmaceutical manufacturers the ability to reproducibly characterize with greater resolution and speed, various charge states of intact biomolecules. This improved monitoring capability helps manufacturers ensure high product quality and efficacy.
In 2004, Waters introduced its Acquity UPLC system that revolutionized the quality of LC separations while significantly increasing sample throughput compared to the use of traditional HPLC technology. The company’s new Protein-Pak Hi Res IEX columns are ideally suited for use on its Acquity System that is optimized to maximize sensitivity while maintaining chromatographically important component resolution. These combined technologies dramatically enhance the characterization of monoclonal antibodies, recombinant proteins, DNA or RNA and vaccine components.
The UPLC SEC Solution enables the biopharmaceutical manufacturers to meet new quality control regulations. This is the industry’s only UPLC size exclusion Chromatography Solution. It provides the manufacturers to separate and quantify monoclonal antibodies (mAb) and their aggregates in less than four minutes, faster than with conventional liquid chromatography, and still meet FDA requirements. “It helps the customers to overcome challenges of developing novel bio-therapeutics in a shorter time and at lower costs. This process produces superior longterm performance by maximizing efficiency while minimizing column-to-column variability,” said Dr. Dorothy Phillips, Director, Chemistry Operations Strategic Marketing ,Waters Division.
Reinforcing the impact of Acquity UPLC technology’s application range, along with the Patrol UPLC System Dr. Rohit Khanna, Vice President Worldwide Marketing, Waters Division said “Early feedback from customers is that this system provides a powerful bridge for customers who currently rely on HPLC but want the performance of UPLC today and in the future. The product combines performance, simplicity and flexibility to help more laboratories realize the scientific and business benefits of sub-2-ìm (micron) particle column technology. Furthermore, the introduction of this system allows organizations to standardize their approach to LC with a common technology platform that makes the future transition from HPLC- to UPLC-based methods straightforward and practical from compound discovery to product release.
For the characterization of 2-AB labelleddd glycans from glycoproteins, Waters is combining its ACQUITY UPLC BEH Glycan Columns with the ACQUITY UPLC System equipped with fluorescence detection. Current FDA regulations require that firms developing and manufacturing therapeutic proteins are able to accurately characterize the glycans attached to those proteins to ensure the efficacy and safety of a biopharmaceutical product.
High throughput chromatography laboratories are tasked with analyzing large numbers of samples, each typically requiring off-line solid phase extraction (SPE). Today Waters is introducing an alternative to this off-line SPE process by combining the benefits of UPLC separating power with on-line, automated SPE. A UPLC-based system with on-line SPE technology can streamline the analysis of samples by providing analyte extraction, concentration, separation, and detection in one turnkey solution.