arGEN-X has launched NHance, its latest cutting-edge technology enabling the creation of truly differentiated human antibody therapeutics.
NHance technology significantly prolongs the circulation time of therapeutic antibodies in the human body by engineering of the antibody constant region (Fc). The technology provides a new treatment paradigm in terms of reduced antibody dosing, increased efficacy and improved overall convenience to the patient.
Nhance is superior to existing Fc engineering approaches delivering superior pharmacokinetics without impairing the antibody's Fc-mediated cell-killing effects. The technology has been thoroughly validated, including through PK studies in appropriate pre-clinical models.
NHance is based on proprietary Fc region mutations and was invented by Dr Sally Ward, professor of Immunology at the University of Texas Southwestern Medical Centre, a world renowned pioneer in this field of antibody biology. arGEN-X has acquired an exclusive global license to the technology.
arGEN-X will apply the NHance technology both to its partners' antibody discovery programmes and to its own therapeutic antibody pipeline. In addition, arGEN-X intends to make the technology available to antibody-focused companies through non-exclusive licenses.
“Our validated SIMPLE (Superior Immunodiversity with Minimal Protein Lead Engineering) Antibody platform, which delivers variable regions unrivalled in their functional diversity and therapeutic utility, is key to arGEN-X's success,” says Prof. Dr Hans de Haard, chief scientific officer. “We had previously complemented the SIMPLE platform with state-of-the-art ADCC-enhancement through our Potelligent license agreement with BioWa. We are now further strengthening our cutting-edge capabilities with NHance to ensure the optimal differentiation of our antibody products. This suite of technologies underpins our evolution into a real therapeutic antibody powerhouse.”
Dr Torsten Dreier, chief development officer of arGEN-X, comments further: “I am thrilled by the therapeutic potential of NHance, which delivers increased efficacy in settings where sustained antibody dosing is critically important. NHance is a great solution for improving the dosing convenience for chronically ill patients as well as maximizing the cost-effectiveness of therapeutic antibody treatments.”
arGEN-X is a preclinical stage biopharmaceutical company that is rapidly leveraging the power of its broadly applicable, proprietary SIMPLE Antibody platform to generate fully human antibodies with differentiated qualities and outstanding therapeutic potential.
NHanceis an arGEN-X proprietary technology capable of enhancing the half life of a therapeutic antibody in the human systemic circulation. It achieves this through 2 specific mutations in the antibody Fc region (at His433 and Asn434), resulting in an improved affinity at acidic pH for the antibody for binding to the neonatal Fc receptor. This receptor is responsible for recycling the antibody within the human body. Enhanced antibody serum levels may result in a higher therapeutic effect of this antibody, lower material requirements of the antibody for the same therapeutic effect, and/or reduced dosing frequency of the antibody.
The technology may further enhance the transport across the mucosal barrier, enabling alternative routes of antibody administration. The SIMPLE Antibody and NHance platforms are covered by broad patent claims, enjoying an independent, unencumbered patent position and are free of target gatekeeping restrictions.