JCR Pharmaceuticals Co., Ltd. and Eisai Co., Ltd. (Eisai) have concluded a feasibility study agreement, under which they will examine the possibility of applying JCR's proprietary blood-brain-barrier (BBB) penetration technology, J-Brain Cargo to the discovery of new treatments.
Under the terms of this agreement, JCR and Eisai will perform collaborative research using the J-Brain Cargo technology and certain pharmaceutical candidate compounds of Eisai's choice, aiming to create innovative pharmaceutical products primarily for diseases of the central nervous system.
J-Brain Cargo enables delivery of target substances across the BBB through a certain receptor expressed on the surface of vascular endothelial cells. JCR studies confirmed BBB penetration of J-Brain Cargo combined target substance as 20 to 100 times the target substance alone. It is an innovative technology which will provide pharmaceutical compounds of small or large molecules with the capacity to pass through the BBB. A substantially large portion of the pharmaceutical injected intravenously should be able to reach inside the brain and confer its effect. Significant improvements are expected for neurological disorders for which little improvements have been possible.
The conclusion of this agreement is expected to have a minor impact on consolidated financial results for the year ending March 31, 2016 for both companies.
In order to prevent various toxic substances from damaging brain tissue, it is essential to maintain stability in the brain through a function that limits the transfer of physical substances from the bloodstream to the brain. Consequently, it is necessary to allow energy sources for neural activity, such as amino acids and glucose, to pass through, while acting as a barrier to prevent most other substances from freely entering the brain. This barrier function is formed by tight junctions of endothelial cells that line the inside of brain capillaries (capillaries outside the brain adhere relatively loosely with endothelial cells, allowing various substances to pass through the tissue). While it is difficult for large molecules such as highly water-soluble substances and proteins to penetrate this barrier, nutrients and other essential materials are able to selectively pass the BBB by a system consisting of various receptors and transporters in the microvascular endothelial cells of the brain. Conversely, any unnecessary substance that enter the microvascular endothelial cells of the brain for some reason are prevented from invading the brain by transporters that will excrete these materials back into the bloodstream.
JCR is a specialty pharma engaged in the research, development, manufacture and marketing of biopharmaceuticals and regenerative medicine with a focus on rare diseases.
Eisai is a leading global research-based pharmaceutical company headquartered in Japan, and aims to be a human health care (hhc) company that gives first thought to patients and their families, and to increasing the benefits health care provides.