Dr Reddy's Laboratories: exports bulk actives, branded formulations and generic formulations to over 60 countries. A few of its bulk drugs such as norfloxacin, ciprofloxacin and enrofloxacin enjoy a large customer base. Dr Reddy's generic formulations have also become popular in quality-conscious regulated markets such as the US, Europe and Japan. The company has filed 64 patents. It has set up a research subsidiary, Reddy US Therapeutics Inc., in Atlanta, USA.

Aurobindo Pharma: The Rs 1,050 crore Aurobindo has business in over 70 countries. Known to be key player in semi-synthetic penicillin, and cephalosporins, the company has presence in SSPs, anti-virals, CNS, cardio-vascular, gastroenterology segments as well. Aurobindo has established wholly owned subsidiaries in China and Hong Kong, a joint venture in US and representative offices in a few countries.

Natco Pharma Ltd: is another notable player from AP. Besides bulk actives and dosage forms, the company provides services like contract research, contract manufacturing and clinical trials, from phases I to IV. The company has gained a foothold in the oncology segment by launching a series of high-end specialty treatments over last two years.

Suven Pharmaceuticals: develops and supplies pharmaceutical and agro chemical intermediates for New Chemical Entities (NCEs) and APIs. The company's manufacturing facilities include fine chemicals, pyrimidines, purines, imidazoles, indoles and speciality intermediates. Suven's main thrust is in Contract Research And Manufacturing Services (C-R-A-M-S) which is serving as many as 22 global Life Sciences and Fine Chemical companies.

Suven Life Sciences USA LLC, its wholly owned subsidiary, recently acquired the assets of the New Jersey-based Synthon Chiragenics Corporation, the global player in carbohydrate- based Chiral technology for pharmaceuticals.

Biological E Ltd: has a presence in sera and vaccines, oncologicals, cardio-vascular, bulk drugs, formulations and herbal products. The company has established alliances with world-renowned pharma companies such as Evans Medical of the UK, Solvay & Cie of Belgium (veterinary products), Pasteur Meraux Connaught of France (sera and vaccines) and ICI, an exclusive marketing tie-up for animal health products.

Divi's Labs Ltd: is a leading manufacturer APIs. It has a state-of-the-art multi-purpose plant at Choutupal, in Nalgonda district, and a second plant at Visakhapatnam. The company is among the top 10 producers of naproxen in the world and 90 per cent of the product is being exported to several countries, including USA and Europe. Besides naproxen, Divi's exports dextrome thorphan, iopamidol, nabumetone, phenyl ephedrine and phen procumar.

Matrix Laboratories: is another major player in API production. With US FDA approved facililty located at Hyderabad, the company has a strong presence in CNS drugs, quinolone anti-bacterials, anti-retrovirals and anti-histamines.

The company recently acquired the Ranbaxy-owned Vorin Laboratories and the Sriram Group owned Medicorp Technologies Ltd. The two companies had been subsequently merged with Matrix Labs. Focusing mainly on synthetic research and process development, Matrix has 6 labs with a team of 70 scientists. The company's major customer spreads across 80 countries.

Hetero Drugs Ltd: made a mark being the first in AP in producing all the anti-retrovirals like indinavir sulphate, nelfnavir, efavirenz, lopinavir, ritonavir, lamivudine, zidovudine , stavudine, abscavir sulphate etc. The company markets its products to over 50 countries and recently penetrated the regulated markets in US, Canada and Europe.

Neuland Laboratories: has two world-class manufacturing facilities on the outskirts of Hyderabad. The company claims to be the largest manufacturer of albuterol sulfate in the world with US FDA approval and Certificate of Suitability from the European Dept for the Quality of Medicines, Council of Europe. It has also a US FDA approved manufacturing facility for ranitidine HCl Form1, ciprofloaxcin and latnoprost. The company exports to over 65 countries worldwide, including USA, Canada, Europe, Latin America, Korea, Japan, Australia and South Africa.

Global Bulk Drugs and Fine Chemicals: is a supplier for a wide range of APIs and drug intermediates. The company's manufacturing facilities conform to US FDA, TGA, WHO, cGMP and ISO 9001 standards. The company has two dedicated facilities and one multi-purpose plant at a single location. Its diverse product range includes cardio-vascular, anti-depressant, anti-diabetic and other segments.

Glochem Industries Ltd: is a public limited which is doing business in bulk drugs, drug intermediates and speciality chemicals. GIL has tie-ups with companies in India and abroad, including US and Europe, for contract manufacturing and custom synthesis. GIL has been developing, manufacturing and delivering tailor-made fine chemicals and intermediates for the leading pharmaceutical and fine chemical companies on exclusive basis.

Some of the other leading bulk drugs manufacturing companies in the state include Krebs Biochemicals Ltd, Gland Pharma, SMS Pharmaceuticals Ltd, Virchow Laboratories Ltd, Sri Krishna Pharmaceuticals, Sreepathi Pharmaceuticals and Anu's Laboratories Ltd.