Advinus Therapeutics Ltd, a drug discovery and development company and P2D Bioscience, a central nervous system (CNS) focused specialty pharmaceutical company have inked an R&D collaborative pact to develop therapies for attention deficit hyperactivity disorder (ADHD).

ADHD is the most commonly diagnosed psychiatric disorder in children, with symptoms continuing into adulthood up to 50 per cent of cases. Recent estimates show that approximately 4.7 percent of American adults live with ADHD. These estimates worldwide are influenced by diagnostic tools as evidenced by the apparent prevalence rate in the US growing from 12 per 1,000 children in the 1970's to 34 per 1,000 in the 1990's.

Timely diagnosis and treatment of ADHD results in the significant reduction in clinical symptoms, however, not all individuals respond to current ADHD medications. Further, current ADHD medications have significant side effects. P2D and Advinus are co-developing a new class of ADHD treatments. These drugs demonstrate increased efficacy due to their higher affinity for the target receptor as well as improved safety due to enhanced selectivity.

"Academic institutions and their spinoff biotech companies are beginning to play increasingly important role in discovering innovative drug candidates and at the same time will continue to depend on partners to develop these assets. The P2D ADHD programme is a classical example of value Advinus provides to such institutions and benefits it derives from such collaborations. We are delighted to establish this exemplary and synergistic relationship with P2D”, said Dr. Rashmi Barbhaiya, CEO and MD of Advinus."

"P2D has been active in partnering with Indian pharmaceutical development companies for the past several years. Advinus was identified by our Indian-based team as the premier pre-clinical and early-stage clinical development company in southeast Asia. P2D partnered with Advinus because of their drug development expertise and experience. We are honoured to be selected as one of Advinus' drug development partners for their risk/reward sharing program which has accelerated the development of our early stage drug candidates, " said Dr. Frank Zemlan, CEO and Chairman of P2D Bioscience.

Advinus  offers end-to-end pre-clinical and early clinical development services to the global pharmaceutical and biotech industry while creating long term value through internal and collaborative drug discovery. The Discovery unit located in Pune is fully integrated from hit to preclinical candidate. Advinus Development in Bangalore offers an integrated service platform for process chemistry, DMPK, clinical pharmacology, safety assessment, analytical R&D, bioanalytical and formulation development.

P2D Bioscience is a specialty pharmaceutical company focused on developing innovating drugs that fulfill unmet medical needs in the treatment of central nervous system and pulmonary disorders.