Aoxing Pharmaceutical a specialty pharmaceutical company focusing on research, development, manufacturing and distribution of narcotic and pain-management products, announced that its operating subsidiary in China, Hebei Aoxing Pharmaceutical Group Company, has been granted a patent by the State Intellectual Property Office of The People's Republic of China for naloxone sub-lingual film. The Chinese patent, ZL2005.1.0125279.7, covers a unique sub-lingual film formulation of naloxone that can be dissolved rapidly under the tongue.

Naloxone is an opioid receptor antagonist that is used clinically to relieve life-threatening depression of the central nervous system and respiratory system, caused by overdose of morphine and other opioids. It may also be used as an adjunctive therapy to increase blood pressure in the treatment of septic shocks. It is most commonly injected intravenously for fastest action. Oral delivery is used in emergent care due to slow and poor absorption. However, injection is inconvenient and requires a nurse to administer it.

The sub-lingual film developed by Aoxing Pharma can be dissolved in under 30 seconds and allows the drug to diffuse into the blood through tissues under the tongue. The rapid and more efficient absorption of the formulation makes it a convenient alternative to injection. Naloxone is an opioid receptor antagonist that is used clinically to relieve life-threatening depression of the central nervous system and respiratory system, caused by overdose of morphine and other opioids. It may also be used as an adjunctive therapy to increase blood pressure in the treatment of septic shocks. It is most commonly injected intravenously for fastest action. Oral delivery is used in emergent care due to slow and poor absorption. However, injection is inconvenient and requires a nurse to administer it.

The sub-lingual film developed by Aoxing Pharma can be dissolved in under 30 seconds and allows the drug to diffuse into the blood through tissues under the tongue. The rapid and more efficient absorption of the formulation makes it a convenient alternative to injection.

Zhenjiang Yue, chairman and CEO of Aoxing Pharma, commented, “I would like to thank our research and development team for its dedication in driving forward this unique product, now proprietary to Aoxing. The convenient administration of naloxone could win critical time in emergency and save lives. We look forward to developing this new therapeutic delivery method for this important market.” Zhenjiang Yue, further added “I would like to thank our research and development team for its dedication in driving forward this unique product, now proprietary to Aoxing. The convenient administration of naloxone could win critical time in emergency and save lives. We look forward to developing this new therapeutic delivery method for this important market.”