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Clinical Data acquires Adenosine Therapeutics
Newton, Massachusetts | Monday, August 11, 2008, 08:00 Hrs  [IST]

Clinical Data has acquired Adenosine Therapeutics, LLC, a developer of drug products based on its extensive portfolio of composition of matter and method of use patents relating to selective adenosine receptor modulators. In exchange for all of the company's operating assets, Clinical Data paid $11 million in cash, and entered into a $22 million, five-year promissory note and a separate $3.2 million, 32-month promissory note. Contingent consideration of up to $30 million in cash may be paid on achievement of certain regulatory and commercial milestones.

The acquisition of Adenosine Therapeutics significantly expands Clinical Data's PGxHealth Division's pipeline of therapeutics, adding drug candidates in cardiology, diabetes, inflammatory diseases, and sickle cell anemia. The acquisition further enhances PGxHealth's pipeline with Stedivaze (apadenoson), which is expected to enter phase-3 testing in 2009 as a pharmacologic stress agent for myocardial perfusion imaging. Sales of the leading adenosine product used as a pharmacologic stress agent totalled approximately $330 million in 2007.

"This transaction broadens our portfolio of drug candidates in selected specialty markets," said Drew Fromkin, President and chief executive officer of Clinical Data. "We believe that combining our pharmacogenomic expertise with Adenosine Therapeutics' broad estate of highly selective adenosine receptor agonists and antagonists could produce targeted therapeutics and companion biomarker tests across a number of therapeutic areas, with a development path made more efficient with the incorporation of biomarkers."

Two compounds in the Adenosine Therapeutics pipeline are the subject of licensing option agreements. Novartis holds an option to partner on the development of ATL844, in preclinical study for the treatment of diabetes and asthma, and a confidential partner holds an option on another compound in preclinical development for an ophthalmic indication.

Adenosine is a naturally occurring molecule produced in many organs and tissues. Cellular responses to adenosine affect many physiologic processes, among them vasodilatation, heart Astellas Pharma. Fiscal Year 2007 results rhythm, and glucose control. Adenosine Therapeutics' molecular library consists of small molecules that act as selective agonists or antagonists at one of four adenosine receptor subtypes: A1, A2A, A2B, and A3.

"We are particularly excited about the chance to apply our biomarker expertise to these compounds at the clinical development and pre-clinical development stage," noted Carol Reed, MD, chief medical officer for Clinical Data.

"Adenosine's scientific team has made promising discoveries relating to genetic variants in adenosine receptors and disease states such as diabetes.

We believe that pursuing biomarker strategies from the early stages of clinical trials will enable us to realize a more efficient development pathway resulting in drugs targeted to the segment of the patient population most likely to respond," he said.

"This deal was made on very favourable terms, and is precisely the sort of opportunity we have been seeking to leverage our pharmacogenomic expertise against a promising set of clinical and preclinical drug candidates. In addition, our cardiology sales force may be expanded to handle the launch of Stedivaze, once marketing approval of that drug is obtained," Fromkin concluded.

Adenosine Therapeutics was co-founded in 1999 by University of Virginia Professor and vice chair for Research of Medicine Joel Linden, PhD, and entrepreneur Robert Capon. Its scientists are among the world's authorities on the pharmacologic and physiologic roles of adenosine and its receptor subtypes.

Clinical Data is a global biotechnology company unlocking the potential of molecular discovery, from Targeted Science to Better Healthcare.

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