DNAnexus, Inc., the leader in cloud-based genome informatics and data management, and BioNano Genomics, Inc., the leader in physical genome mapping, have entered into a collaboration that offers access to BioNano’s genome analysis algorithms and pipeline (IrysSolve) on the DNAnexus Platform. IrysSolve is designed to provide researchers with the capability of performing comprehensive analysis of the whole genome, with the computational power and scalability of the DNAnexus cloud genomics platform.

DNAnexus provides a secure and compliant cloud environment where researchers can run high-speed, high-throughput, parallel analyses in a rapid and cost-efficient manner. The flexibility of the DNAnexus platform supports multiple data types including long and short-read sequencing and next-generation mapping formats. Through this collaboration, BioNano offers a pre-configured, full-scale version of the BioNano Genomics computational pipeline, including applications for assembly, hybrid scaffolding, and structural variation calling. This integrated solution provides the ability for enterprises of any size to run IrysSolve from anywhere in the world, and the ability to collaborate securely and share data efficiently in a centralized and controlled environment.

The McDonnell Genome Institute at Washington University is one of the first institutions to employ the Irys System to improve the quality of the human reference genome, the gold standard against which new sequencing projects are compared.

“We are using whole genome BioNano mapping data to confirm the accuracy of whole genome assemblies, and to inform annotation and structural variation analysis,” said Tina Graves-Lindsay, Leader of the Reference Genomes Group at the McDonnell Genome Institute at Washington University St. Louis.

“DNAnexus has eased the process of performing whole genome mapping through BioNano’s Irys System with a turnkey solution.”

“We are very excited to join technologies with DNAnexus, to provide researchers with fast and cost-effective access to the whole genome analysis computational power they need to reach their discoveries,” said Erik Holmlin, Ph.D., president and chief executive officer of BioNano Genomics.

“We believe with these tools, researchers will spend less time waiting for analyses and more time focusing on results.”

“We are pleased to support BioNano to further improve single-molecule genome sequencing and mapping technology,” said Richard Daly, CEO of DNAnexus. “We are seeing a growing need for clearer knowledge of structural variations in the clinic to help with disease diagnosis. DNAnexus provides a global network, democratizing this technology and making it accessible to labs of all sizes anywhere in the world.”