Gen-Probe has signed a supply and purchase agreement with F. Hoffmann-La Roche Ltd. and its affiliate Roche Molecular Systems, Inc. under which Gen-Probe will purchase products for use in molecular diagnostic assays for human papillomavirus (HPV).

Under the agreement, Roche will manufacture DNA probes for HPV, which Gen-Probe will purchase at agreed-upon transfer prices. Gen-Probe also has agreed to pay initial manufacturing fees in two instalments. Gen-Probe plans to use HPV probes supplied by Roche in Aptima format HPV test kits to detect high-risk subtypes of HPV.

"Developing an HPV test is an important part of Gen-Probe's long-term strategy to enter new markets where there are important medical needs and attractive commercial opportunities," Henry L. Nordhoff, chairman, president and chief executive officer of Gen-Probe said adding, "A highly sensitive and specific HPV assay will fit perfectly with our strong STD franchise, and be an ideal high-volume test to expand the menu of our fully automated, high-throughput TIGRIS system."

HPV is a group of viruses that includes more than 100 different subtypes. Some types infect the skin and cause warts, whereas others are sexually transmitted. Persistent infection with high-risk HPV subtypes is acknowledged as the primary cause of cervical cancer, and high-risk subtypes are found in more than 99 per cent of cervical cancer cases.