The United States Patent and Trademark Office (USPTO) has awarded two new patents for GeNO LLC, a privately held, advanced development-stage technology company.  The company now has a total of nine issued US patents for its proprietary nitric oxide generation and delivery technology.

GeNO's eighth patent (8,057,742) on Nitrosyl (nitric oxide) for inhalation concerns the conversion of nitrogen dioxide (NO2) to nitric oxide (NO) using the GeNO cartridge technology to scavenge nitrogen dioxide that may have been formed, for example, in the gas lines, and converting it back into nitric oxide. The system could be used as an add-on to existing technology and would remove residual toxic nitrogen dioxide impurity from the system. Importantly, this new patent does not expire until January 2026.

The ninth patent (8,066,904) relates to the controlled generation of nitric oxide. This patent describes a controlled release matrix made up of a nitric oxide-releasing agent, nitric oxide precursors, and a polymer binder into a unitary structure for delivering nitric oxide to a patient. The potential applications could include either an oral formulation or a salve. This patent does not expire until November 2027.

"These patents not only build on our company's strong intellectual property but also address some important possibilities to improve patient treatment with nitric oxide," said GeNO LLC Founder and President David Fine. "Using our proprietary technology the company has developed several distinct nitric oxide delivery platforms."

Nitrosyl could add valuable options for clinicians treating a range of serious pulmonary and cardiac diseases with inhaled nitric oxide. GeNO's plans for both in-hospital and ambulatory inhaled nitric oxide systems would help address the cost, complexity and lack of portability of current treatment regimens, and would potentially reach a much larger group of patients. At present, GeNO's delivery technologies are investigational and are not approved by regulatory authorities.

GeNO is currently performing two phase 2 trials: one, as a Pilot Study in Pulmonary Arterial Hypertension (PAH) and a second dose-escalation trial for the Treatment of Pulmonary Hypertension in patients with PAH and Pulmonary Hypertension secondary to Idiopathic Pulmonary Fibrosis (PH-IPF).

GeNO LLC, founded in 2006, is a privately held, advanced development-stage technology company that is developing innovative nitric oxide (NO) generation and delivery platforms to enable the true potential of inhaled nitric oxide to be realized.