Invicro LLC, a Konica Minolta company and a leading provider of imaging services and software for research and drug development, recently announced the launch of AmyloidIQ, a new and advanced algorithm that quantifies Amyloid scans for use in subject stratification and clinical trials of Alzheimer’s disease therapies.

This novel algorithm calculates a single measure of the brain’s amyloid level denoted amyloid load, offering increased efficiencies within clinical imaging trials.  The new method encodes expert domain knowledge into an artificial intelligence algorithm that can accurately calculate the level of amyloid plaques in the brain. Test data from the Alzheimer’s Disease Neuroimaging Initiative database containing over 900 [18F] Florbetapir scans were analyzed with the new method and resulted in a 50% increase in power over other existing methods.   This technique opens the possibility of detecting smaller changes sooner, allowing clinical trials to run more efficiently and cost effectively by using reduced-size trials while achieving the same results.

Co-inventor and EVP of Quantitative Data Sciences for Invicro, Professor Roger Gunn, states, “By encoding expert domain knowledge into a computer algorithm for image analysis of amyloid scans we can increase power, reducing cost and timelines for clinical trials of novel AD therapeutics. This provides more powerful tools to pharmaceutical companies working in this important and challenging area.”

Professor Gunn collaborated with Dr. Alexander Whittington to develop and launch this innovative technique, which was presented and well received at the 12th Annual Human Amyloid Imaging Conference (HAI) in Miami, Florida. HAI 2018 provides an opportunity for academia and industry to share cutting edge advances in understanding amyloid pathology and its measurement in neurodegenerative disease.

Based in Boston, MA, Invicro was founded in 2008 with the mission of improving the role and function of imaging in translational drug discovery and development across all therapeutic areas. Invicro’s multi-disciplinary team provides a full range of image informatics, engineering and operational services.

Konica Minolta, Inc. (Konica Minolta) is a global digital technology company with core strengths in imaging and data analysis, optics, materials, and nano-fabrication.