Researchers at Kyushu University of Japan, in collaboration with Perlegen Sciences, Inc., have identified common patterns of human DNA sequence variation, or haplotypes, in the Japanese population.

By combining a unique set of DNA samples collected at the medical institute of bioregulation at Kyushu University with Perlegen's high throughput, whole-genome analysis approach, based on next generation Affymetrix GeneChip technology, the collaborators identified common haplotypes that can be used to conduct comprehensive genetic research on human disease and variable response to medicines.

"Understanding the patterns of genetic variation in the Japanese population will greatly enhance our ability to identify genes associated with disease and drug response. The unique approach of this study complements the recently completed international HapMap project. Both studies make critical contributions to enabling personalised medicine in Japan," stated Dr. Kenshi Hayashi, professor of the research center for genetic information, medical institute of bioregulation at Kyushu University.

The collaboration between Kyushu University and Perlegen Sciences was particularly effective in identifying long-range haplotypes (over one million bases long).

"With this study, Dr. Hayashi and his colleagues at Kyushu University have made an important contribution to medical research in Japan. It will enable researchers to identify the genetic factors that determine why drugs work well for some patients, but not for others," said David Cox, chief scientific officer of Perlegen.