News + Font Resize -

Merck, Paratek sign pact for aminomethylcycline antibiotic PTK 0796
Whitehouse Station, N.J | Saturday, March 11, 2006, 08:00 Hrs  [IST]

Paratek Pharmaceuticals, Inc. has entered into an exclusive, worldwide collaborative development and license agreement with Merck & Co., Inc. -- through an affiliate -- for PTK 0796, a novel, broad-spectrum aminomethylcycline (AMC) antibiotic with oral and intravenous (IV) formulations currently in Phase I clinical testing.

Under the terms of the agreement, Merck provided undisclosed upfront funding, will assume primary responsibility for clinical development of the IV and oral formulations of PTK 0796 and has the right to market such products worldwide. Paratek will participate in clinical development and be eligible to receive payments upon achievement of certain milestones; these payments could total as much as $127 million once PTK 0796 is approved for marketing. Paratek will also receive royalties on net sales and have the opportunity to co-promote the IV formulation of PTK 0796 in the United States.

According to the company release, PTK 0796 represents a significant advance over the well-known tetracycline family, and has been shown to be highly effective in animal models at treating increasingly problematic, clinically prevalent infections caused by gram-positive bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA), and by gram-negative, atypical and anaerobic bacteria, including those resistant to currently available classes of antibiotics and known to cause diseases such as pneumonias, urinary tract infections, skin diseases and blood-borne infections in both the hospital and community settings.

Post Your Comment

 

Enquiry Form