Merck Serono, the bio-pharmaceutical, division of Merck, The Institute of Cancer Research (ICR), and the Wellcome Trust, London, announced a co-development and licence agreement building on two independent research programmes at both the ICR and Merck Serono to identify inhibitors of tankyrase, an enzyme of the poly (ADP-ribose) polymerase family. The collaboration will be jointly funded by Merck Serono and the Wellcome Trust. The existing drug discovery programme at the ICR is supported by a Wellcome Trust Seeding Drug Discovery Award.

In a joint effort, a team led by Dr. Chris Lord and Professor Alan Ashworth at the ICR and a research group at Merck Serono will aim to progress chemical compounds that have emerged from both organisations’ tankyrase inhibitor programmes towards clinical development. At the end of the collaboration period, Merck Serono will take over full responsibility for the selected clinical development candidate, with the goal of bringing a new cancer therapeutic drug to patients.

Dr. Chris Lord, Team Leader in the Division of Breast Cancer Research at The Institute of Cancer Research, London, said: “Tankyrase inhibitors provide a unique opportunity to target one of the most common characteristics of cancer cells their dependency on the so-called ‘Wnt signaling’ pathway. Both Merck Serono and the group at the ICR have already made notable progress in developing tankyrase inhibitors. Working with Merck Serono will allow us to jointly accelerate our programme with the aim to ultimately make tankyrase inhibitors available to cancer patients.”“We are delighted to work together with Dr. Chris Lord and Professor Alan Ashworth.

With this partnership, we aim to harness the already well advanced tankyrase programmes at both ICR and Merck Serono and hope to ultimately translate these in to novel treatment options for cancer patients. We will build on a joint compound base of potent tankyrase inhibitors and will leverage both sites’ scientific knowledge about the ‘Wnt pathway’ that plays a major role in signal transduction for tumor growth”, said Dr.Andree Blaukat, Head of the Translational Innovation Platform Oncology at Merck Serono. “The interest of the Wellcome Trust shows its belief in our researchers’scientific data. It also shows the importance of academia-industry collaboration models in pharmaceutical development to progress the most promising investigational compounds into clinics with the aim of bringing them to patients.”

“This agreement highlights the importance of translational funding, such as the awards provided under the Seeding Drug Discovery scheme, to reduce the risk of drug discovery programmes so that they become attractive to partners who have the ability to bring a product to market”, said Dr. Ted Bianco, Director of Innovations at the Wellcome Trust. “We welcome the strategic collaboration with Merck Serono, which brings together a world-leading academic drug discovery group, and an industry partner with such a strong commitment to oncology, to give the programme the best possible chances of success.”Some of the most promising advances in cancer research have been small-molecule inhibitors which block the activity of members of the poly (ADP-ribose) polymerase (PARP) enzyme family, which includes the enzyme tankyrase.

Under the terms of the agreement, Merck Serono will make milestone payments based on achieving regulatory and sales goals plus royalty payments on net sales of future products discovered or developed under the agreement.