Novartis will present data demonstrating the latest advancements from its oncology research program at the 58th American Society of Hematology (ASH) Annual Meeting & Exposition, San Diego, December 3-6, and the San Antonio Breast Cancer Symposium (SABCS), San Antonio, December 6-10. Presentations will focus on a number of cancers, including leukemia, lymphoma, myelofibrosis and breast cancer, as well as chronic iron overload.

The data reinforce Novartis’ dedication to developing transformative therapies and treatment strategies to improve and extend the lives of people living with these diseases.

“Novartis continues to invest in not only creating new medicines for underserved patient communities, but also in redefining cancer treatment goals,” said Bruno Strigini, CEO, Novartis Oncology. “Our ASH and SABCS data, including personalized cell and targeted therapies of the future, underscore our core belief in treating each patient as an individual, not just the disease.”

Most notable among Novartis’ clinical data to be featured at the two meetings are from the ongoing registrational trials for investigational CTL019 and LEE011 (ribociclib). The CTL019 data will be included in upcoming regulatory submissions. Novartis also recently received US Food and Drug Administration Priority Review for LEE011 (ribociclib) plus letrozole as first-line treatment for postmenopausal women with HR+/HER2- advanced or metastatic breast cancer, based on results from the MONALEESA-2 study.

Novartis will also be presenting safety, efficacy and quality of life data at ASH from its hematology portfolio, including an investigational use for Tasigna (nilotinib). Five-year pooled overall survival data for Jakavi (ruxolitinib) in patients with myelofibrosis and patient-reported health-related outcomes from patients with chronic immune thrombocytopenia taking Promacta (eltrombopag) will also be presented.

Because CTL019, LEE011 (ribociclib), ABL001, PKC412 (midostaurin) and BKM120 (buparlisib) are investigational compounds, the safety and efficacy profiles have not yet been fully established. Access to these investigational compounds is available only through carefully controlled and monitored clinical trials. These trials are designed to better understand the potential benefits and risks of the compounds. Because of the uncertainty of clinical trials, there is no guarantee that CTL019, LEE011 (ribociclib), ABL001, PKC412 (midostaurin) and BKM120 (buparlisib) will ever become commercially available anywhere in the world.