Pfizer Inc. and the Massachusetts Institute of Technology (MIT) held the official ground breaking of Pfizer's Cardiovascular, Metabolic and Endocrine Diseases (CVMED) and neuroscience research units at 610 Main Street, Cambridge, Massachusetts.

In September, Pfizer announced it had entered into a 10-year lease agreement with MIT for more than 180,000 square feet. Taking part in the ground breaking event were: Pfizer Board Member Dennis Ausiello, Physician-in-Chief, Massachusetts General Hospital; Chief Scientific Officer, Partners Healthcare; and Jackson Professor of Clinical Medicine, Harvard Medical School; Pfizer President of Worldwide Research and Development Mikael Dolsten; other members of the company’s Executive Leadership Team; MIT President Susan Hockfield; Massachusetts Governor Deval Patrick; and Cambridge Mayor David Maher.

Dr. Allen Krieger, who is living with early-stage Alzheimer’s disease, also attended the ceremony with his wife Jeanne, along with Alzheimer's Association Massachusetts/New Hampshire chapter Vice President of Medical and Scientific Affairs, Jerry Flaherty.

In February Pfizer announced a strategic shift in research and development, to focus the company’s efforts on a smaller number of research areas where the potential for impact is greatest, including its CVMED and Neuroscience research units. As part of this shift, Pfizer announced it would substantially boost its presence in Cambridge by moving these two important research units there. This relocation makes Pfizer the second largest biopharmaceutical company in Massachusetts in terms of number of employees.

“We deliberately chose to move to Cambridge, Massachusetts, as a key part of our research and development strategy, in order to foster productive collaborations between our drug discovery experts and the outstanding scientists of Cambridge’s world-class institutions,” said Pfizer Worldwide R&D President Mikael Dolsten.

“This is a very exciting period in Pfizer research and development during a time of great change while we strengthen our innovative core with the goal of delivering the best medicines to patients,” said Dr. Dolsten.

Pfizer plans to bring around 400 new research jobs to Cambridge. In addition to relocating key Pfizer scientists to the area, the company anticipates hiring a significant number of scientists for the two research units, including biologists, chemists and individuals with other areas of research expertise.

“Physical proximity to the medical R&D community in Massachusetts is designed to encourage frequent and meaningful relationships with leading biomedical research institutions,” said Rod MacKenzie, senior vice president of Pfizer PharmaTherapeutics R&D.

“By bringing together our drug discovery scientists with the best contemporary biologists and scientific minds in Cambridge, we aim to provide the most stimulating environment for our researchers to invent the next generation of medicines. Tackling the symptoms of diabetes and moving to prevention; reducing the symptoms and slowing disease progression of Alzheimer’s disease; taking the control of lipids and cardiovascular risk reduction to unprecedented new levels - the opportunities to positively impact human health are endless,” said MacKenzie.

“It is great news that Pfizer is boosting its presence in Massachusetts and bringing close to 400 new jobs here,” said Governor Deval Patrick. “Companies like Pfizer know that Massachusetts can’t be beat when it comes to providing a high-quality workforce and high-quality of life, thanks to our nation-leading investments in education, health care and innovation.”

“Kendall Square’s thriving innovation cluster makes a strong case for the creative power of proximity. Pfizer has supported MIT research for more than a decade, and we are convinced that establishing their new research facility right next door will accelerate the cycle of discovery and innovation. Connecting MIT’s pioneering research with Pfizer’s commitment to delivering real-world solutions for patients is a potent formula for impact,” said MIT President Susan Hockfield.

"We're thrilled to see Pfizer expand its footprint in the City of Cambridge, bringing new jobs and resources to our community. We're also grateful to MIT for serving as the catalyst for this initiative and for its role in continuing to grow our innovation economy," said Mayor David Maher.