Polyclone Bioservices and Peaccel, a bio-IT company that provides predictive solutions for protein engineering services, has signed a memorandum of understanding (MoU) to utilize Polyclone’s in silico enzyme engineering framework (eEF) to strengthen its protein engineering services.

The collaboration is focused on offering specifically enzyme engineering services to optimize enzymes for better activity, stability and specificity under process conditions.

“We are looking to command a leading commercial presence in predictive solutions for directed molecular evolution and protein engineering through our sets of algorithms. Now Polyclone’s technology for enzyme engineering services is perfectly complementary to our services. We believe this  partnership is a great opportunity to leverage our respective commercial presence in the fast growing enzyme engineering industry,” said Dr Frédéric CADET, VP - Business Development, Peaccel.

“Polyclone’s in-depth expertise in molecular modelling and simulation complements perfectly our own expertise on semi-rational design and rational screening. We have very good traction with their scientists. Altogether, this provides us the opportunity to offer a fully integrated solution to the enzyme engineering market,” said Dr Bernard Offmann, VP – Research, Peaccel.

“Our enzyme engineering framework - eEF is a smart integration of proprietary algorithms and processes for high throughput and high confidence predictions of enzyme and protein modifications for desired properties. The solution integrates computational library design, directed evolution and statistical modelling of sequence–function relationships while considering the intermediary stages of enzyme-substrate interaction to achieve its goals,” said Naveen Kulkarni, CEO, of Polyclone Bioservices.

“With the recognition of importance of molecular dynamics (MD) in this year’s Nobel prize for chemistry, it has further affirmed our approach, and the extensive experience that Peaccel brings to this collaboration, provides unparalleled advantage to our customers in solving highly complex enzyme productivity issues and we hope to contribute to better financial outcomes combining this with a greener objective,” added Kulkarni.