Romaco, a leading global supplier of processing and packaging equipment, will take advantage of the Mumbai trade fair, P-MEC India and to present innovative solutions for aseptic filling, tableting, granulation and coating of pharmaceutical products based on Macofar, Kilian and Innojet technologies.

The event P-MEC will be held from December 1 to 3, 2015. The exhibits on show will demonstrate Romaco’s extensive expertise when it comes to processing pharmaceutical liquids, powders and granulates. The innovative Macofar MicroMaxX 18 microdosing machine will make its first appearance in Asia since the successful world premiere at ACHEMA 2015.

The Macofar MicroMaxX 18 microdosing machine continues the engineering specialist’s decades-long tradition of solutions for aseptic microdosing. It is equally suitable for processing both pharmaceutical powders and sterile liquids and meets all the requirements for downstream freeze-drying. The Macofar MicroMaxX 18 features a dual dosing disc which allows multiple dosing into the same vial; alternatively, the product can be filled in two separate process steps. Thanks to the new weight control system, all vials can now be weighed individually for the first time. The Macofar MicroMaxX 18 is the fastest in the market today with one hundred percent weight control, with an output of 12,000 vials an hour. It can be equipped with various containment systems owing to its modular concept. Sterile external access to all components is assured via glove ports.

The newest generation of Romaco’s Macofar LVI 6 was specifically developed for handling sterile ophthalmic medications. This double indexing machine achieves a maximum output of 150 glass or plastic bottles per minute. The monobloc design of the aseptic rotary filler unites the three main operations, namely liquid filling as well as the application of the dropper and screw cap. This compact machine is moreover ideal for use with an open RABS (Restricted Access Barrier System). A special recirculation system can be integrated in the product tank for filling suspensions. Microbiological checking, particle presence checking and nitrogen flushing before and after filling the bottles can be supplied as options. The 100 per cent torque control provides optimal process control in case of eye drops. The Macofar LVI 6 can be flexibly configured and is available with weight control on request.

The Romaco Kilian S 370 Prime is designed for fully automatic production of mid-sized batches and compresses up to 300,000 tablets an hour. It offers excellent value for money and the low initial capital investment is a convincing argument for pharmaceutical manufacturers all over the world. This compact press combines several highlights such as GAMP compliant automation, an integrated lifting system to speed up die table exchanges and patented, wear-free brake magnets. Retooling and cleaning times are reduced to a minimum because easy access is possible to all components while the space efficient design means no external electrical cabinet is needed. The machine is controlled via the integrated HMI touch panel and Vicon visualisation software, so that operation is very straightforward. The Romaco Kilian S 370 Prime can be equipped with an automatic tablet tester and a trending function on request.

Cool, fast & clean – these are the hallmarks of the Romaco Kilian KTP 720X tablet press for mono and bi-layer formats. “Cool”: the special compression rollers, bolts and bearings reduce mechanical friction, enabling the temperature in the process area to be maintained at a constant level below 30°C. The press is consequently ideal for processing temperature sensitive medications such as Ibuprofen or Metformin. “Fast”: this double-sided rotary press compresses up to 1,020,000 tablets an hour absolutely reliably at high speed. What’s more, all product and format changes can be completed quickly and easily. “Clean”: the optimised hygienic design improves product quality and makes the process more reliable. The hermetic separation of the compaction area and the machine compartment means no product gets into the service area. The patented punch bellows protect the tablets from contamination with lubricants. The ingenious press design simultaneously restricts cleaning to a minimum. The Romaco Kilian KTP 720X is very simple to operate thanks to the new generation of HMI panels featuring zoom and swipe navigation.

The STYL’ONE Evolution single-stroke tablet press provides an effective demonstration of Romaco’s laboratory expertise. The STYL’ONE is predestined for formulating mono-layer, multilayer or core tablets (tab in tab) in a broad array of R&D applications as well as for producing very small batch sizes. It is equipped with a gravity or paddle force fill shoe and is capable of compressing up to five layers with three different components. The production process on any standard rotary press can be simulated precisely using ANALIS, the intelligent PAT software. The user selects the machine model, tablet thickness and compression force for this purpose. ANALIS then automatically determines the optimal compression parameters for the machine. Only a tiny quantity of powder is needed for ultra-precise test batches with up to 1,200 tablets per hour. Apart from developing new formulations, the Romaco Kilian STYL’ONE Evolution can also be utilised in a targeted way to make manufacturing processes more efficient or troubleshoot errors.

The internationally patented technology of the Romaco Innojet VENTILUS V 2.5 is based on the air flow bed method originally developed by Dr. h.c. Herbert Hüttlin. This laboratory-scale machine processes particles from 10 µm to 30 mm in diameter, such as powders, granulates, pellets, tablets, capsules and numerous other free-flowing bulk materials. A proven all-rounder, it is the perfect granulation and coating system for pharmaceutical, chemical and food products. The enhanced processing efficiency permits up to 25% shorter batch times. The homogeneous flow conditions inside the cylindrical product container enable extremely gentle intermixing of the batch. The process air is controlled by the ORBITER booster, an ingenious container bottom consisting of overlapping circular plates. Together with the ROTOJET, the central bottom spray nozzle, the booster forms an innovative functional unit that meets all the requirements for linear scale-ups. The air flow bed technology ensures accurate control of the product movement and equally precise application of the spray liquids. The resulting formulations achieve the required release profile with between 10 and 15 per cent less spray liquid.