Phenomenex Inc. has developed a new and versatile pentafluorophenyl propyl (PFP) core-shell phase called Kinetex F5 columns to overcome the reproducibility and performance limitations of existing PFP columns in the market.

Global leader in the analytical instruments manufacture, Phenomenex has been in the forefront in the research and manufacture of advanced technologies for the separation sciences. The company is coming with new and advanced technologies from time to time. In the year 2014, the company had introduced an advanced analytical instrument called Kinetex EVO C18 in October and a new SecurityGuard cartridge system to protect all GPC columns in the laboratories.

Having successfully launched the new products last year, this year too Phenomenex has begun with the introduction of Kinetex F5 core-shell columns with improved performance.

Kinetex F5 is a robust pentafluorophenyl propyl (PFP) core-shell phase that overcomes reproducibility and performance limitations of existing PFP and F5 products in the market. After extensive internal and external testing found that existing PFP and F5 fully porous and core-shell products produced sporadic basic compound adsorption and analyte retention time shifting, Phenomenex, in partnership with customers, redefined the industry standard and developed this new core-shell pentafluorophenyl.

The new Kinetex F5 phase delivers improved reproducibility compared to other PFP or F5 columns on the market and can significantly reduce method development time with its dynamic and responsive chemical functionality. It is an ideal solution for HPLC/UHPLC development work with its combination of polar and non-polar interactions including hydrogen bonding, electrostatic, hydrophobic, aromatic and steric/planar mechanisms. Additional versatility of this phase gives scientists the ability to use reversed phase, 2D-LC, HILIC, SFC or even 100 per cent aqueous separation modes. With its fluorinated groups and carbon ring structure, the Kinetex F5 is an excellent choice for both polar and non-polar compound separations as well as challenging methods that include halogenated, conjugated or isomeric compounds.

Kinetex F5 is available in 2.6 and 1.7 µm particle sizes and delivers all the advantages of Phenomenex’ Core-Shell Technology including better resolution, higher efficiency, easy method transferability and cost savings from reduced solvent consumption. The Kinetex 2.6 µm F5 provides performance comparable to sub-2 µm particles on both standard HPLC and UHPLC systems. The 1.7 µm column delivers 20 per cent greater efficiencies than fully porous sub-2 µm products.  Explaining about the new development, Simon Lomas, brand manager for Phenomenex said, “These new Kinetex F5 columns are the result of years of research, development and customer input. With better, more accurate and higher performance products like the Kinetex core-shell F5, scientists can continue to push the current limits of separation science.”