Agilent Technologies Inc, the world's premier measurement company and a technology leader in communications, electronics, life sciences and chemical analysis, and BioTrove Inc. announced that they have signed an agreement to co-market the Agilent 6410 Triple Quadrupole Mass Spectrometer with BioTrove's RapidFire high-throughput sample preparation systems. The two systems together provide an integrated solution for ultra-high-throughput preparation and analysis of in vitro biological assays in pharmaceutical drug research.
"This relationship enables clients to integrate the fastest sample-preparation system on the market with the strength of leading-edge analytical mass spectrometry. It significantly benefits pharmaceutical companies that want to spend less time and money discovering new leads and developing more effective medicines," said Guenter Nill, general manager, pharmaceutical and biotech market, Agilent.
Using innovative microfluidic technology for sample preparation and analysis faster than eight seconds per sample, RapidFire Mass Spectrometry (RF-MS) eliminates bottlenecks created by traditional mass spectrometry throughput. It has been used by 10 of the top 15 pharmaceutical companies as an established drug-discovery tool for more than four years. RF-MS is routinely used in applications including the high-throughput screening of previously intractable drug targets, cytochrome P450 inhibition and other pre-clinical ADME assays, as well as in directed evolution studies.
The Agilent 6410 Triple Quadrupole LC/MS establishes a new standard for value in a triple quadrupole mass spectrometer, delivering outstanding sensitivity and great ease of use along with traditional Agilent reliability. Femtogram-level sensitivity and rugged, reliable performance make this the instrument of choice for drug discovery and development.
"The Agilent-BioTrove collaboration provides an improved, integrated high-throughput screening solution, enabling biopharmaceutical companies to better use their talent, time and targets. BioTrove's expertise in sample preparation for high-throughput screening and early ADME is a natural complement to Agilent's strength in analytical mass spectrometry. Together, we are enabling walk-away analysis of lead compounds against valuable targets that would be otherwise impossible to screen, helping biopharma clients meet the challenge of accelerating drug discovery research," said Al Luderer, Ph.D., president and CEO, BioTrove.
BioTrove, Inc. offers two innovative technology platforms: RapidFire, which enables the acceleration of drug discovery and pipeline decisions, and OpenArray, which advances genomic research in a wide range of life science fields, including agriculture, disease research, bio-defence, and public health. With more than half of the world's ten largest pharmaceutical companies as clients, and partnerships with prestigious research and public health centres around the world, BioTrove's products and services ensure that an industry committed to accuracy and speed can meet business goals.
RapidFire Mass Spectrometry (RFMS) uses an innovative microfluidic technology to facilitate analysis at faster than 10 seconds per sample, eliminating the bottleneck created by traditional mass spectrometry throughput. RFMS is routinely used in many applications including the high-throughput screening of previously intractable drug targets, cytochrome P450 inhibition and other ADME assays and directed evolution studies.
The OpenArray Platform enables genomics researchers to generate SNP and real time qPCR data in the hundreds of thousands of data points per day, significantly increasing the number of samples analysed while significantly decreasing the time and cost required. The flexible format and nanoliter scale of the OpenArray system allows for easy adjustment of sample and assay numbers, achieving economical, high-throughput genomics.